{"id":65,"date":"2023-09-26T16:18:27","date_gmt":"2023-09-26T07:18:27","guid":{"rendered":"https:\/\/websv.okayama-u.ac.jp\/phy2\/?page_id=65"},"modified":"2023-10-05T19:23:00","modified_gmt":"2023-10-05T10:23:00","slug":"research","status":"publish","type":"page","link":"https:\/\/websv.okayama-u.ac.jp\/phy2\/en\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"65\" class=\"elementor elementor-65\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3d24ec3 e-flex e-con-boxed e-con e-parent\" data-id=\"3d24ec3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d751d22 elementor-widget elementor-widget-heading\" data-id=\"d751d22\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Naruse team<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1ec014f e-flex e-con-boxed e-con e-parent\" data-id=\"1ec014f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4e63116 elementor-widget elementor-widget-text-editor\" data-id=\"4e63116\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p data-sourcepos=\"7:1-7:189\">In our laboratory, we study the effects of mechanical stress on the human body. Mechanical stress is a physical stimulus that can include stretching, pressure, shear stress, and gravity.<\/p>\n<p data-sourcepos=\"7:1-7:189\">In the condition of hypertension, the heart is exposed to both pressure and stretching stimuli. Also, when jumping or landing, the knee joint experiences strong forces, and cartilage cells are exposed to high pressure. These mechanical stresses are known to be the causes of diseases such as heart failure and cartilage damage.<\/p>\n<p data-sourcepos=\"11:1-11:148\">We use cultured cells, experimental animals, or human subjects to study the effects of mechanical stress on tissue physiology and diseases. Our research findings are expected to be useful for the prevention and treatment of diseases caused by mechanical stress.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-031a27d e-flex e-con-boxed e-con e-parent\" data-id=\"031a27d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7945f55 elementor-widget elementor-widget-heading\" data-id=\"7945f55\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">1. Molecular mechanism of mechanotransduction<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1e139ff e-flex e-con-boxed e-con e-parent\" data-id=\"1e139ff\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c82cd18 e-con-full e-flex e-con e-child\" data-id=\"c82cd18\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5cb76f2 elementor-widget elementor-widget-image\" data-id=\"5cb76f2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"248\" height=\"183\" src=\"https:\/\/websv.okayama-u.ac.jp\/phy2\/wp-content\/uploads\/sites\/12\/2023\/10\/naruse_img02.jpeg\" class=\"attachment-large size-large wp-image-637\" alt=\"hemodynamic force\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-079931a e-con-full e-flex e-con e-child\" data-id=\"079931a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5adee0f elementor-widget elementor-widget-text-editor\" data-id=\"5adee0f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Mechanical stress can be classified into three main types: stretching, shear stress, and hydrostatic pressure. However, our understanding of the receptors for these stresses is still very limited. We are investigating the molecular mechanisms of mechanotransduction using cardiovascular cells.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fa64cd7 e-flex e-con-boxed e-con e-parent\" data-id=\"fa64cd7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7adc707 e-con-full e-flex e-con e-child\" data-id=\"7adc707\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7f0873c elementor-widget elementor-widget-image\" data-id=\"7f0873c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"210\" height=\"157\" src=\"https:\/\/websv.okayama-u.ac.jp\/phy2\/wp-content\/uploads\/sites\/12\/2023\/09\/naruse_img06.jpeg\" class=\"attachment-large size-large wp-image-66\" alt=\"microfluidic channel\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e76beac e-con-full e-flex e-con e-child\" data-id=\"e76beac\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7b20c9b elementor-widget elementor-widget-text-editor\" data-id=\"7b20c9b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Microchannel to apply shear stress<\/strong><\/p>\n<p>It is possible to generate high shear stress and laminar flow in a microchannel with a width of 500 \u03bcm and a height of 50 \u03bcm. Cell culture is also possible in this microchannel.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5377990 e-flex e-con-boxed e-con e-parent\" data-id=\"5377990\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9cb1330 elementor-widget elementor-widget-heading\" data-id=\"9cb1330\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">2. Mechanical stress and pathology<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8da99c8 e-flex e-con-boxed e-con e-parent\" data-id=\"8da99c8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-218b826 e-con-full e-flex e-con e-child\" data-id=\"218b826\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-62409e4 elementor-widget elementor-widget-image\" data-id=\"62409e4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"266\" height=\"200\" src=\"https:\/\/websv.okayama-u.ac.jp\/phy2\/wp-content\/uploads\/sites\/12\/2023\/10\/naruse_img08.jpeg\" class=\"attachment-large size-large wp-image-638\" alt=\"mechanical stretch\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6472b39 e-con-full e-flex e-con e-child\" data-id=\"6472b39\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-404d149 elementor-widget elementor-widget-text-editor\" data-id=\"404d149\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>When vascular endothelial cells cultured in a stretching chamber are subjected to uniaxial cyclic stretching, they align perpendicular to the stretching direction.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-942352a e-flex e-con-boxed e-con e-parent\" data-id=\"942352a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-cab6af4 e-con-full e-flex e-con e-child\" data-id=\"cab6af4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d1245a7 elementor-widget elementor-widget-image\" data-id=\"d1245a7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"156\" height=\"200\" src=\"https:\/\/websv.okayama-u.ac.jp\/phy2\/wp-content\/uploads\/sites\/12\/2023\/10\/naruse_img07.jpeg\" class=\"attachment-large size-large wp-image-639\" alt=\"nature\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-269a8af e-con-full e-flex e-con e-child\" data-id=\"269a8af\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9a6117c elementor-widget elementor-widget-text-editor\" data-id=\"9a6117c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>When vascular endothelial cells located in the intima of a blood vessel are subjected to a 20% stretch stress, the intracellular calcium ion concentration increases with a single stimulus.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-27d3385 e-flex e-con-boxed e-con e-parent\" data-id=\"27d3385\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cec269f elementor-widget elementor-widget-heading\" data-id=\"cec269f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">3. Mechanical regenerative medicine<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-48b990f e-flex e-con-boxed e-con e-parent\" data-id=\"48b990f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e34197e elementor-widget elementor-widget-text-editor\" data-id=\"e34197e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Our bodies are three-dimensional structures that are subjected to stretch and compression stresses. Therefore, we have developed a system to apply stretch and compression stresses to three-dimensional cultured cells. In addition, we are developing a completely synthetic self-assembling peptide gel scaffold that will replace collagen for future regenerative medicine.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-92c92e7 e-flex e-con-boxed e-con e-parent\" data-id=\"92c92e7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2bd2bab elementor-widget elementor-widget-image\" data-id=\"2bd2bab\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"565\" height=\"228\" src=\"https:\/\/websv.okayama-u.ac.jp\/phy2\/wp-content\/uploads\/sites\/12\/2023\/09\/ShellpaPro.jpeg\" class=\"attachment-large size-large wp-image-68\" alt=\"ShellpaPro\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b87e5ad e-flex e-con-boxed e-con e-parent\" data-id=\"b87e5ad\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c1b4d41 e-con-full e-flex e-con e-child\" data-id=\"c1b4d41\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6bb06c5 elementor-widget elementor-widget-image\" data-id=\"6bb06c5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"275\" height=\"311\" src=\"https:\/\/websv.okayama-u.ac.jp\/phy2\/wp-content\/uploads\/sites\/12\/2023\/09\/peptidegel.png\" class=\"attachment-large size-large wp-image-69\" alt=\"peptidegel\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-137b24d e-con-full e-flex e-con e-child\" data-id=\"137b24d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-eab00e9 elementor-widget elementor-widget-text-editor\" data-id=\"eab00e9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The molecular structure of self-assembling peptide gels. Beta-sheet structures are formed by intermolecular interactions between alternating charges, leading to nanofibrillation. It constitutes a gel with a water content of over 99%.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5053930 e-con-full e-flex e-con e-child\" data-id=\"5053930\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3b43397 elementor-widget elementor-widget-image\" data-id=\"3b43397\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"565\" height=\"178\" src=\"https:\/\/websv.okayama-u.ac.jp\/phy2\/wp-content\/uploads\/sites\/12\/2023\/09\/panacea_mainimg.png\" class=\"attachment-large size-large wp-image-71\" alt=\"panacea_mainimg\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>\/*! elementor &#038;#8211 [&hellip;]<\/p>\n","protected":false},"author":35,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-65","page","type-page","status-publish","hentry"],"aioseo_notices":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-23 02:02:34","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/websv.okayama-u.ac.jp\/phy2\/en\/wp-json\/wp\/v2\/pages\/65","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/websv.okayama-u.ac.jp\/phy2\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/websv.okayama-u.ac.jp\/phy2\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/websv.okayama-u.ac.jp\/phy2\/en\/wp-json\/wp\/v2\/users\/35"}],"replies":[{"embeddable":true,"href":"https:\/\/websv.okayama-u.ac.jp\/phy2\/en\/wp-json\/wp\/v2\/comments?post=65"}],"version-history":[{"count":14,"href":"https:\/\/websv.okayama-u.ac.jp\/phy2\/en\/wp-json\/wp\/v2\/pages\/65\/revisions"}],"predecessor-version":[{"id":649,"href":"https:\/\/websv.okayama-u.ac.jp\/phy2\/en\/wp-json\/wp\/v2\/pages\/65\/revisions\/649"}],"wp:attachment":[{"href":"https:\/\/websv.okayama-u.ac.jp\/phy2\/en\/wp-json\/wp\/v2\/media?parent=65"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}